Skin conditions

Recent studies have suggested that the endocannabinoids system is found within in the skin and is implicated in various biological processes including control and well-balanced proliferation, differentiation, and survival, as well as immune competence and/or tolerance, of skin cells.

Disruption in the endocannabinoid system is thought to be associated with the development of multiple pathological conditions of the skin including acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer. A healthy endocannabinoid system can help to fight skin allergies, inflammation, pain and itchy dry skin, acne and seborrhea, dermatitis, systemic sclerosis and other skin diseases.

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   2. Li, Shan-Shan, et al. Cannabinoid CB2 receptors are involved in the regulation of fibrogenesis during skin wound repair in mice. Molecular Medicine Reports. 13: 3441-3450. 2016. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805070/)
   3. Derakhshan, N. and Kazemi, M. Cannabis for refractory psoriasis -high hopes for a novel treatment and a literature review. Current Clinical Pharmacology. 11(2): 146-147. 2016. (https://pubmed.ncbi.nlm.nih.gov/27164964/)
   4. Olah, Attila. Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes. The Journal of Clinical Investigation. 124(9): 3713-3774. 2014. (https://pubmed.ncbi.nlm.nih.gov/25061872/)
   5. University of Colorado Anschultz Medical Campus. Cannabinoids may soothe certain skin diseases, say researchers. Science Daily. 2017. Accessed on June 9, 2019. (https://www.sciencedaily.com/releases/2017/04/170418094315.htm)
   6. Eagleston, LRM., et al. Cannabinoids in dermatology: a scoping review. Dermatology Online Journal. 24(6). 2018. (https://pubmed.ncbi.nlm.nih.gov/30142706/)
   7. Stander, S. Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus. Hautarzt. 57(9): 801-807. 2006. (https://pubmed.ncbi.nlm.nih.gov/16874533/)
   8. Karsak, M. et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science. 316: 1494-1497. 2007. (https://pubmed.ncbi.nlm.nih.gov/17556587/)
   9. Wilkinson, J.D. and E.M. Williamson. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. Journal of Dermatological Science. 45: 92. 2007. (https://pubmed.ncbi.nlm.nih.gov/17556587/)
   10. Telek, A. et al. inhibition of human hair follicle growth by endo- and exocannabinoids. FASEB Journal. 21(13): 3534-3541. 2007. (https://pubmed.ncbi.nlm.nih.gov/17567570/)