Sleep disorders

CBD has been found to be effective in the treatment of many sleep-associated problems including somnolence, poor quality of sleep at night, obstructive sleep apnea, insomnia, REM sleep behavior disorder among those with Parkinson’s disease, nightmares associated with PTSD and sleep disrupted by chronic pain.

Preclinical research shows that CBD increases acetylcholine levels in a brain region related to wake control and may be useful to promote wakefulness modulation.
CBD has been shown in multiple studies to reduce anxiety and may be beneficial for people who experience anxiety-related sleep problems.

1. Murillo-Rodriguez, E. et al. The nonpsychoactive cannabis constituent cannabidiol is a wake-inducing agent. Behavioral Neuroscience. 122(6): 1378-1382. 2008. (https://pubmed.ncbi.nlm.nih.gov/19045957/)
2. Murillo-Rodriguez, E. The role of the CB1 receptor in the regulation of sleep. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 32: 1420-1427. 2008. (https://pubmed.ncbi.nlm.nih.gov/18514375/)
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6. Linares, Ila, M. et al. No acute effects of cannabidol on the sleep-wake cycle of healthy subjects: a randomized, double-blind, placebo-controlled, crossover study. Frontiers in Pharmacology. 9(315): 1-8. 2018. (https://pubmed.ncbi.nlm.nih.gov/29674967/)
7. Carley, David, W. et al. Pharmacotherapy of apnea by cannabimimetic enhancement, the PACE Clinical Trial: effects of dronabinol in obstructive sleep apnea. Sleep. 41(1): 1-13. 2018. (https://pubmed.ncbi.nlm.nih.gov/29121334/)
8. Murillo-Rodriguez, Eric. Et al. Systemic injections of cannabidiol enhance acetylcholine levels from basal forebrain in rats. Neurochemical Research. 43(8): 1511-1518. 2018. (https://pubmed.ncbi.nlm.nih.gov/29876791/)
9. Shannon, Scott, et al. Cannabidiol in anxiety and sleep: a large case series. The Permanente Journal. 23: 18-41. 2019. (https://pubmed.ncbi.nlm.nih.gov/30624194/)